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Life Science Research Professional

Company: Stanford Medicine
Location: Daly City
Posted on: May 4, 2022

Job Description:

The Department of Microbiology and Immunology is seeking a Life Science Research Professional 1 to perform basic functions and activities involved in defined research projects, and independently conduct and analyze experiments as a member for the Yang Lab. Our research group focuses on understanding the mechanisms responsible for viral replication and development of new strategies to combat viral pathogens. We combine chemical biology, medicinal chemistry, and molecular virology approaches to tackle challenges in both basic and translational research. Over the past decade, our efforts have centered on two significant problems: first, addressing the challenges that limit our current arsenal of antivirals and second, understanding the specificity and function of host lipids in RNA virus replication. We are keenly interested in discovery of new antiviral targets and strategies and leveraging these discoveries to develop first-in-class small molecule antivirals. We also have a strong interest in developing or adapting tools from chemistry, chemical engineering, and biophysics to probe new areas of virology.

The LSRP will perform antiviral assay to characterize the antiviral activity of small molecules and map the steps of viral replication cycle affected by small molecules; biochemical and biophysical assay such as SPR, BLI, alphascreen for target validation; mutagenesis study to understand the development of antiviral resistance and interaction of small molecules and target. The LSRP will work on a team including medicinal chemists, structural and computational chemists, virologist and biochemists. The desire and ability to collaborate are essential.
Candidates must be willing to work with pathogenic viruses (e.g. dengue, zika, Japanese encephalitis virus etc.)

Duties include:

  • Plan approach to experiments in support of research projects in lab and/or field based on knowledge of scientific theory.
  • Independently conduct experiments; maintain detailed records of experiments and outcomes.
  • Apply the theories and methods of a life science discipline to interpret and perform analyses of experiment results; offer suggestions regarding modifications to procedures and protocols in collaboration with senior researcher.
  • Review literature on an ongoing basis to remain current with new procedures and apply learnings to related research.
  • Contribute to publication of findings as needed. Participate in the preparation of written documents, including procedures, presentations, and proposals.
  • Help with general lab maintenance as needed; maintain lab stock, manage chemical inventory and safety records, and provide general lab support as needed.
  • Assist with orientation and training of new staff or students on lab procedures or techniques.
    *- Other duties may also be assigned

    DESIRED QUALIFICATIONS:
    • Bachelor's degree in biological science discipline and at least 1-2 years of relevant laboratory experience.
    • Ability to work independently and cooperatively with a team.
    • Solid written and verbal communication skills.

      Familiarity with the following experimental techniques highly desired:
      • Mammalian, insect, and bacteria cell culture and maintenance.
      • Propagation and titering of viruses.
      • Standard molecular biology techniques including SDS-page and western blot analysis, DNA/RNA isolation, RT-qPCR, immunofluorescence assay.
      • Careful attention to detail is required to perform the functions of this job as well as an outstanding. ability to maintain sterile conditions and to communicate with others on the team.
      • Experience in virology and chemical biology study is a plus.

        Candidate will need to demonstrate aptitudes in foresight, planning and ability to organize.

        EDUCATION & EXPERIENCE (REQUIRED):

        Bachelor's degree in related scientific field.

        KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):
        • General understanding of scientific principles. Demonstrated performance to use knowledge and skills when needed.
        • Demonstrated ability to apply theoretical knowledge of science principals to problem solve work.
        • Ability to maintain detailed records of experiments and outcomes.
        • General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.
        • Ability to work under deadlines with general guidance.
        • Excellent organizational skills and demonstrated ability to accurately complete detailed work.

          PHYSICAL REQUIREMENTS*:
          • Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.
          • Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.
          • Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.
          • Must have correctible vision to perform duties of the job.
          • Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.
          • Ability to lift heavy objects weighing up to 50 pounds.
          • Ability to work in a dusty, dirty, and odorous environment.
          • Position may require repetitive motion.
            *- Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.

            WORKING CONDITIONS:
            • May require working in close proximity to blood borne pathogens.
            • May require work in an environment where animals are used for teaching and research.
            • Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.
            • Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.
            • May require extended or unusual work hours based on research requirements and business needs.

              WORK STANDARDS:
              • Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.
              • Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors bases on training and lessons learned.
              • Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University's Administrative Guide, http://adminguide.stanford.edu.

                As an organization that receives federal funding, Stanford University has a COVID-19 vaccination requirement that will apply to all university employees, including those working remotely in the United States and applicable subcontractors. To learn more about COVID policies and guidelines for Stanford University Staff, please visit https://cardinalatwork.stanford.edu/working-stanford/covid-19/interim-policies/covid-19-surveillance-testing-policy

                Additional Information
                • Schedule: Full-time
                • Job Code: 4945
                • Employee Status: Regular
                • Pay Grade: E
                • Department URL: http://cmgm.stanford.edu/micro/
                • Requisition ID: 93633 As an organization that receives federal funding, Stanford University has a COVID-19 vaccination requirement that will apply to all university employees, including those working remotely in the United States and applicable subcontractors. To learn more about COVID policies and guidelines for Stanford University Staff, please visit https://cardinalatwork.stanford.edu/working-stanford/covid-19/interim-policies/covid-19-surveillance-testing-policy

Keywords: Stanford Medicine, Daly City , Life Science Research Professional, Other , Daly City, California

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